Recent content by Markov_Spirello

  1. M

    Arthritis trial data: Advanced multivariate stats problem.

    So if I have a pain in both of my two thumbs in the lowest joint, that would be "2"? YES It's slightly more complicated - the raw score is binary yes/no for two aspects of joint involvement - tenderness and swelling. We are only interested in presence of disease in the joint yes/no so have...
  2. M

    Arthritis trial data: Advanced multivariate stats problem.

    patients are assessed at multiple timepoints and its the change between baseline and t=x (probably 3 months) that we're interested in, unless there are major methodological advantages in including the other timepoints.
  3. M

    Arthritis trial data: Advanced multivariate stats problem.

    Depending on the dataset we use n is between 150 and 450 per group. The patients are different and randomised to one of two treatments.
  4. M

    Arthritis trial data: Advanced multivariate stats problem.

    Many thanks for your quick reply. As joints always come in pairs, we’re actually combining left and right for reasons related to the hypothesis so we have 33 “joint pairs” which may be 0, 1 or 2; neither affected, 1 affected, both affected. Healthy is 0, lass healthy is 1 and unhealthy would be...
  5. M

    Arthritis trial data: Advanced multivariate stats problem.

    I am a doctor planning a post-hoc exploratory analysis of some clinical trial data and would like some suggestions as to the best approach. Patients with arthritis have many inflamed joints; in clinical trials, doctors test 66 of these for tenderness and swelling. The result is trinary: 0; no...