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    Appropriate p-value correction in two cohort meta-analysis (discovery / validation)

    Dear all, I would like to request your help and opinions on a meta-analysis setup utilizing two completely independent cancer cohorts, where one acts as discovery data set, while the other is meant as validation cohort. To 'integrate' both cohorts, I would like to select genes by FDR in...
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    Minimal set of new predictor variable(s) and added value to existing predictor

    Hi everyone, I am working on gene expression data for 15 genes and am supposed to derive a minimal predictive set of genes that can be used as a marker profile for disease progression. So far, I created Kaplan-Meier curves for all 15 candidates and performed tested for association with bad...
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    Two-dimensional outlier detection

    Hi all, I was wondering if you could give me some suggestions to detect two-dimensional outliers, i.e. for values depending on the variables. A simple example: 15 12 30 11 9 11 15 29 16 18 12 10 150 20 10 15 11 40 18 20 The 150 should be detected as outlier, whilst the other...
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    Transform data for outlier analysis?

    Hey everyone, I have a data set which is log normally distributed and want to detect outliers, so far I used a threshold approach: vector contains the values of interest. outlier detected if: value > ((2*(median absolute deviation(vector))/0.6745) + median(vector) My problem is: is...