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  1. J

    First time poster: question on statistical analyses of treatment groups

    Yes, we perform Kaplan Meier survival analysis. I am not sure what you mean by "quasi-competing event" (?) but I do not think there is any "competition" (?) My first post was maybe a bit confusing and unnecessarily complicated as I was not totally sure what the reviewers was referring to. So...
  2. J

    First time poster: question on statistical analyses of treatment groups

    Thanks a lot for your valuable comments! :) This is a retrospective study and yes, small numbers (underpowering) and non-randomisation are valid concerns, but they are not uncommon in our field. We certainly do not want to "produce" effects with bad statistics, nor do we want to claim an effect...
  3. J

    First time poster: question on statistical analyses of treatment groups

    See the picture on what I want to test for: Would the comment by the reviewer hold true? (Since patients in group C only received treatment Z only if they survived long enough to do so and the survival range in group B is lower than group C, I have to exclude all group B patients that survived...
  4. J

    First time poster: question on statistical analyses of treatment groups

    Thanks again. How about if I want to compare group B vs group C for the potential prognostic factor: Group B a) survival in prognostic factor positive patients b) survival in prognostic factor negative patients Group C a) survival in prognostic factor positive patients b) survival in...
  5. J

    First time poster: question on statistical analyses of treatment groups

    Thank you for getting back to me! Regarding your first question: Well, yes, but in some cases they had progressive disease during treatment Y, so treatment Z was started earlier in some than in other patients. Regarding your second question: Patients were not randomised. Basically the...
  6. J

    First time poster: question on statistical analyses of treatment groups

    Hello all, I wonder if you can help me understand the following comment I received on a study: So, there are 3 patient groups (A, B and C): Group A receives treatment X Group B receives treatment Y Group C received treatment Y followed by treatment Z. Results (the numbers are made up)...