clinical trial

  1. K

    Which test should I use to find the rose among the thorns in SAS studio?

    I have 200 patients who have prescriptions from a pool of 20 drugs, and 100 normal control volunteers who do not take any of the drugs in the pool of 20. Each patient has 0 to 6 prescriptions from the pool of 20 in random combinations. Some of these patients have elevated plasma levels of...
  2. W

    Clinical Trial - sample size for statistically comparable data?

    Hi Everyone In a nutshell - I am looking to undertake an 8 week clinical trial of an equine veterinary health product. I am wanting to analyse corticosteroid concentrations deposited in the keratin of mane hair at Day 1 and then Day 56. I was hoping that 20 horses would be a sufficient...
  3. W

    Clinical Trial - sample size for statistically comparable data?

    Hi Everyone In a nutshell - I am looking to undertake an 8 week clinical trial of an equine veterinary health product. I am wanting to analyse corticosteroid concentrations deposited in the keratin of mane hair at Day 1 and then Day 56. I was hoping that 20 horses would be a sufficient...
  4. T

    please help me justify sample size for a pilot clinical trial

    I'm a bit desperate for statistical help so trying out all avenues. Any guidance appreciated! I need to justify a sample size of 30 or 32 (15 or 16 per arm) for a placebo-controlled pilot clinical trial of a drug. This is all I can afford, but that is not a good enough justification for...
  5. T

    how to justify a sample size for an underpowered pilot study

    moved to biostatics: how to justify a sample size for an underpowered pilot study UPDATE: I reposted this in the biostatistics forum. I also added some more details, mainly my not-fully-formed thoughts about how to proceed. Thanks! I need to justify a sample size of 30 or 32 (15 or 16 per...
  6. L

    Clinical trial - stratified randomization

    Hi all, There is something very basic I don't get about stratified randomization and I was hoping you might be willing to help me with. Say I have a clinical trial for which I would like to recruit 90 patients. I have two alternative treatments I want to test. I also have 2 baseline measures...
  7. S

    clinical trial interpretation

    Hi! given two randomised clinical trials, the first compare treatment A vs B; the second compare treatment A vs B vs C. after enrolment, the investigators decided to combine the arms A and B of the two studies and they have made one single comparison(A vs B), in the other hand they compare the...
  8. C

    Mixed Model Nested Anova or Two sample test?

    Hello Forum Participants, My dissertation research evaluates the effect of a hormone on the epithelium. My data was obtained from a clinical trial with a placebo group and 4 different treatment groups. For each group I have pre and post treatment samples but an unequal number of data points. I...
  9. victorxstc

    Is this study clinical trial or retrospective cohort?

    Hi We have a set of patients with dental implants in their mouths. We wanna evaluate whether implants in each patient's mouth are as sensitive as normal teeth (of the same patient) to tactile stimuli. So it can be a retrospective cohort, because we have split the sample based on the...