Hello everyone,
I need to define the loss of some cells with differential size. In the control population, size distribution is bimodal, each peak seems pretty much gaussian except for the overlapping tails (see attachment). In my cases, cell loss is obvious even though with different magnitude between subjects (from 30% total remaining cells to less than 5%), but I wanted to explore if the loss is homogeneous between the two cell families or if one is more affected.
I came up with two ideas till now:
 categorize the variable in intervals, defining the two peak interval in control population. Then, calculate peak ratio in controls and cases and ttest between the two groups
 pool the control data, use a steamandleaf plot on the continuous variable to identify the two peak value, then analyze only the outer tails (the left one for the lower values and the right one for higher values) to get each curve standard deviations. Select the data to include in each subgroup using a one or twostandard deviation cutoff from each peak, then testing that ratio
Am I completely wrong? better ideas?
I need to define the loss of some cells with differential size. In the control population, size distribution is bimodal, each peak seems pretty much gaussian except for the overlapping tails (see attachment). In my cases, cell loss is obvious even though with different magnitude between subjects (from 30% total remaining cells to less than 5%), but I wanted to explore if the loss is homogeneous between the two cell families or if one is more affected.
I came up with two ideas till now:
 categorize the variable in intervals, defining the two peak interval in control population. Then, calculate peak ratio in controls and cases and ttest between the two groups
 pool the control data, use a steamandleaf plot on the continuous variable to identify the two peak value, then analyze only the outer tails (the left one for the lower values and the right one for higher values) to get each curve standard deviations. Select the data to include in each subgroup using a one or twostandard deviation cutoff from each peak, then testing that ratio
Am I completely wrong? better ideas?
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