#1.

**noninferiority margin of 2.00**for the upper limit of the

**two**-

**sided**95% confidence interval of the hazard ratio

#2. We determined that the enrollment of 1000 patients would provide a

**power of 80%**to show the noninferiority of A at a

**one-sided alpha level of 0.025**, assuming an estimated 1-month incidence of the

**primary efficacy outcome of 7%**with D.

#3 Proportional-hazards assumptions were tested with the use of a g

**eneralized Wald test**for a joint hypothesis on all interaction terms specified in the statistical models

Thank you so much, please explain in layman terms, thanks!!