Multiple Chi square


I have categorical data for each gene: -2, -1, 0, 1, 2

I have 2 groups (group 1 and group 2, with a combined total of 200 cases) and approximately 20,000 genes:


I would like to evaluate the frequency of the categorical data for gene 1 in group 1 vs 2; gene 2 in group 1 vs 2; gene 3 in group 1 vs 2; and so on...

I would think a chi square test would tell me if the occurrence of the gene level (-2, -1, 0, 1, or 2) occurred significantly more often in one group than in the other. Unfortunately, I have approximately 20,000 genes to evaluate. SPSS only lets me enter a maximum of 176 variables in crosstabs. Can this be done in SPSS?

Any help on the best way to approach this would be great. Thanks.