hi!
During the work, certain metabolites in blood plasma are studied (more specifically, the concentrations of metabolites are measured). A test sample and a control group were collected. One of the tasks: To analyze the correlations between the age and significant clinical data groups of the subjects with BRCA1 / 2 positive breast tumor and the changes in amino acids (profile) and in comparison with the control group. (Relevant clinical data here include: cancer stage and treatment stage). For the calculation, I also analyzed the differences in the study sample itself, i.e., whether there was a statistically significant difference, e.g., between the plasma metabolite concentrations of stage I and II patients. The key question I received from my supervisor is: Is it correct to compare the data obtained (metabolite concentrations) in the study group (between subgroups such as different stages and treatment stage) if I compare them later with the control group? maybe someone can explain whether it is correct to compare subgroups within the study sample itself?
During the work, certain metabolites in blood plasma are studied (more specifically, the concentrations of metabolites are measured). A test sample and a control group were collected. One of the tasks: To analyze the correlations between the age and significant clinical data groups of the subjects with BRCA1 / 2 positive breast tumor and the changes in amino acids (profile) and in comparison with the control group. (Relevant clinical data here include: cancer stage and treatment stage). For the calculation, I also analyzed the differences in the study sample itself, i.e., whether there was a statistically significant difference, e.g., between the plasma metabolite concentrations of stage I and II patients. The key question I received from my supervisor is: Is it correct to compare the data obtained (metabolite concentrations) in the study group (between subgroups such as different stages and treatment stage) if I compare them later with the control group? maybe someone can explain whether it is correct to compare subgroups within the study sample itself?