significance of difference across genders between changes in two conditions

I would like to find out whether measured biological changes in a disease condition compared to a healthy control condition differ significantly between the two genders. So instead of classical approaches for testing the significance of the difference between two conditions, I would need to apply a statistical test that assesses the "significance of the difference (across genders) of differences (across disease/health conditions)".
Any pointers on how this could be implemented would be welcome.