software for phase 1 dose and schedule optimisation

#1
is there R or other software for Braun's 2007 Bayesian method for simultaneously optimizing dose and schedule of a new cytotoxic agent (in a phase 1 clinical trial) https://journals.sagepub.com/doi/abs/10.1177/1740774507076934 ?

Also is the principle of optimising dose and schedule similar to that of finding the maximum tolerated doses (MTD) of a dual agent as in Wages method https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521068/pdf/nihms-399865.pdf
(is can Wages approach be used to optimise dose and schedule as well as the dose of two drugs - I believe there is standard software for Wages method)