Statistical analysis of median

Dear all,

For a systematic review as part of my study I tend to analyse if there is a difference in the serum levels of a specific enzyme in patient with a mutation in comparison with the serum levels of the specific enzyme in patients without the mutation. Available studies all report there outcomes in medians with lower and upper limit.

I want to test if there is a difference in the median of these two groups, however my question was what the best test would be to test this difference as it is not a mean with SD.

Best regards,