#### David Wong

##### New Member
Dear All,

Please kindly help me, if i don't get this done by monday, my ass (job) will be on the line!

Anyway, the problem is below:

i have a group of 497 patients (Real World ie. RW)
out of which : 399 Males and 98 Females

from this 497 patients, we started to filter out those with complex diseases and only left with :

201 patients (Simple Case ie. SC)
out of which : 160 Males and 41 Females

The problem is i would need to find out: are these 2 groups of patients significantly different or are they similar? ie. i need to find out the p-value. (p-value of <= 0.05 is considered significant)

I tried using Chi Sq but as these 2 groups are of different sizes, it would not allow me to use this test, so which test i should you for this case??

Really Deeply appreciate if anyone can help me?

Warmest Regards
David Wong

#### lumhearts

##### New Member
Hi David,
What are exactly are you trying to compare? Are you trying to compare RW and SC status by gender? If so, this would give you a 2x2 table. Two rows (Males and Females) and two columns (RW and SC). And for example, you should have 41 females with SC. This should allow for a chi-square stat.

#### Pygm

##### New Member
You can do a chisq test on the (Complex,Simple)X(Male,Female) table. To be precise, this test only tells u whether the sex ratio is significantly different between the two groups approximately.

#### David Wong

##### New Member
You can do a chisq test on the (Complex,Simple)X(Male,Female) table. To be precise, this test only tells u whether the sex ratio is significantly different between the two groups approximately.
Thats exactly what i am trying to find out is the sex ratio whether is it significantly different between the 2 groups.