I have 2 groups with n=6 each with respiratory rate taken at baseline (predose), 1, 2, 3, and 4 hour postdose. I have figures with baseline subtracted means and SD at each timepoint and need to know whether there is a difference between groups. Can it be as simple as running multiple t tests at each timepoint using the baseline subtracted values or would it be best to do a two way anova and compare against the baseline values for each group?