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    Study Design & Power for Pain Research

    --> Thanks for the reply. Yes, pain measures are matched. They're measured before and after being given a drug. We're considering a 30% reduction in pain after being given the drug to be "success", so going from 3 to 2 would be the same as going from 9 to 6, both 33% reduction in pain. So...
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    Study Design & Power for Pain Research

    I am designing a pain study. The outcome is change in pain from a Numeric Rating Scale (NRS), 0-11, pre- and post- treatment. Our original thought was to hypothesize a change of at least 2.0, with a standard deviation of 4.0 yielding an effect size of 0.5, requiring 34 subjects. However, we...