# biostatistics

1. ### Non parametric multivariate analysis. maybe :(

Hello to everyone, i need some help with my statistical analysis. I have two different pharmacokinetic parameters. They result from two different models applied on the same data. These data are baseline and follow up data of 20 subjects. To sum up, for each subject, i have 4 measures: - two...
2. ### estimate a range of measures

Hello everyone, I am a statistics student, I'm studying for a project in my University. I have to analyze the data, I have available the measures in millimeters corrisponding two different types of objects, of course I have already done tests to groups such as t-test, actually these organized...
3. ### N of 1 study looking at complex phenotypes and SNPs

Hi All, I have a complicated question and can't find a resource that answers it comprehensively. I'm designing a study looking for linkage between a complex phenotype; how people respond to various different topical treatments. This will not be published in a scientific journal so will be...
4. ### Study Design for assessing efficacy of New Clinical Sign

Hi! I am looking for some guidance as to what statistical tests I would need to do to know the significance of a study. The situation is this: Disease in Question is Sinusitis Gold Standard for Diagnosis is CT, but is seldom done as not all cases require confirmation. Cost-effectiveness...
5. ### Statistics for regional disease risk factors

Hi, I've data set collected from 700 sheep farms from 5 regions of England (north, south, East, West, Central). The aim is find out if climate variables (maximum temperature, minimum temperature, rainfall) are predictors for animal disease in the regions, so the outcome variable (y) = number of...
6. ### Trying to analyze aggregated data

Hi, I would like to know how it would be possible to make a t-test with aggregated data on SPSS or R. My dataset looks like this: Region......Question.....%positive.......%negative......n 1..............15...............20...................45............2956...
7. ### Regional analysis of disease risk factors

I'm working with a large data set looking at climate variables e.g maximum, minimum temperature etc to see whether these could be risk factors for the regional variation for a sheep disease in 5 different regions within a country. The dependent variable is disease count (number of cases)...
8. ### How should I connect alleles?

I am new at statistics and I have problem that I have no idea how to solve. I have biological data, which includes expression levels (130 patients) for different alleles (I'm analysing SNP's) of different genes (over 500 000 genes). First thing I did was finding those genes, for whom I have...
9. ### PAF through formula or through Conditional Logistic Regression

Hi all, In a large registry dataset of psychiatric patients, if one wants to find the excess risk of schizophrenia patients developing depression, what would be the best method to apply: 1) Use the relevant formula to calculate PAF (Population Attributable Fraction). Formula can be...
10. ### Calculating a one-way anova with just means, stdev, and sample sizes

Hi How can you determine the sum of squares total, sum of squares within and between, only knowing the mean, standard deviation and sample size of two groups e.g., group 1: mean 5.67 SD 3.055 sample size 3 group 2: mean 14.33 SD 2.081 sample size 3 Many thanks for any help and...
11. ### Calculate Incidence rate for disease with fertility/mortality data

I am trying to calculate disease incidence in a certain country. I have the number of cases detected over 10 year period. The disease affects children mostly age 5 and younger, but my inclusion criteria are for children <10 years. I also have the country's fertility rates and child mortality...
12. ### Biostatistics opportunity in a new genomics company

Offering an exciting opportunity for a biostatistician to join a rapidly growing genomics company based in Cambridge, UK If you have experience of developing predictive/prognostic algorithms, a knowledge of clinical genomic sequencing and a desire to make a real impact on the improvement of...
13. ### what stats to use?

Dear All, As I am not experienced in stats I would like to ask for some stats suggestions for a study. study one: control impact with one impacted site and one reference site. Two species and biometrics taken. I need to see if the the impacted site increases biometrics. study two...
14. ### Project Issue.

I am a student of statistics discipline. I have to conduct a project which i can apply in society or nation. My preferable topics are agricultural/technological/environmental statistics. But i am not understanding how can i specialize my topic, make it applicable and can have an ample online...
15. ### Help finding appropriate test when observations are non-independent

I have a data set consisting of data from 7 islands. I have measured the average gene flow between each pair of islands as well as the difference in temperature between each pair of islands. I want to know whether these to variables (average gene flow and "thermal mismatch" are correlated)...
16. ### Help with kaplan meier analysis in SPSS

HI! Thank you very much in advance for helping with my post! I am a phd student, I do surgical research at the carotid artery. My current project looks at plaque echolucency, which is a radiological finding on ultrasound examination. Your carotid artery can either be echolucent (1) or...
17. ### Using a grad class as a prereq for stat/biostat MS in a unique situation.

Hello all, I guess I'll begin with my goal: to obtain an MS in stat/biostats in order to change careers. I do not intend to pursue education beyond the MS level. Also the schools I intend to apply to are not top tier, just solid regional schools where I'd like to settle. I have a unique...
18. ### Clustered data in SPSS

How to insert an already-clustered data set in SPSS? I have a data set where there are repeated laboratory measurements for each patient, that is the patient is the cluster. How to inform SPSS that the patient ID variable is the "clustering" variable? Or is that not possible in SPSS ?
19. ### biostatistics for ordinal variable

The study is perspective. the subject is : the effect of an intervention on antibiogram level I will have a antibiogram value at (4: for clean- 3 for a few- 2 for moderate and 1 for many bacteria) for each patient( 5 patient in every group, 10 patient in control and intervention groip)...
20. ### ?Pearson ?point-biserial correlatiom coefficient for relationship between variables

Hi, I'm new on this forum, thanks for reading my post! I'm trying to figure out if I've used the best method for determining a relationship between variables (calculations done using Excel). I have a cohort of 38 trauma patients of different ages. I have measured their aortic diameter on...