noninferiority

Hello, anyone out there familiar with Trial Sequential Analysis (TSA) software developed by Copenhagen Trial Unit? The free software is available at: http://www.ctu.dk/tsa/downloads.aspx Manual is available here: http://www.ctu.dk/tsa/files/tsa_manual.pdf Summary of my questions up here: 1. How...

Dear all, I was asked to estimate the minimum sample size to set up a RCT comparing a standard dose technique to detect recurrence of disease vs low-dose technique. It seemed to be reasonably to me to think about differences in sensitivity and to suggest a noninferiority trial comparing the...