Appropriate test for two variables


This is my first time posting here, so forgive me if I don't include something. I will follow this post and add more information as needed.

I want to compare two samples, one is a city, and another is a neighborhood in that city, for the same disease. I have the population size, the percentage of respondents who said that they have the disease or prevalence if you will, for both the neighborhood and the city. I also have the 95% CI for the aforementioned.

What test should I use? Are the two samples dependent?

My goal is to compare the neighborhood vs. the city and say that the prevalence of the disease in this particular neighborhood is statistically significantly different from the prevalence of the disease in the city.

Any help would be greatly appreciated. Thank you.