I am now processing data for my thesis and wonder what statistical method would be appropriate to use to compare two of the methods I used.

In the first method, I prepare an ion exchange column by following a given procedure. In the second, I change one parameter in the preparation procedure. In each case, I prepare a total of three parallel ion exchange columns (series).

When a column is prepared, I use it to measure the half-life of a radionuclide (5 times per column) What I want to do in my data analysis is to compare the resulting half-lives from Method 1 and Method 2.

My data set looks something like this:

Method 1:

Series 1: 70,1 - 69,2 - 72,0 - 67,5 - 72,1

Series 2: 66,8 - 70,9 - 71,3 - 73,1 - 70,0

Series 3: xxxxx

Same for method 2

From what I’ve been reading, I believe that paired T-test is not suitable here. Is there any other common statistical analysis I can perform?

i greatly appreciate your help!