Hello guys
I am doing my phd research in molecular biology. I am totally illiterate in statistics that is why i am facing some real problems in my proposal.
coming to the point, below i describe my project in simple words. i need you guys help and comments and suggestions for modifications
I am working on correlation of a certain abnormality in DNA of patient with hepatitis c related cancer. my hypothesis is that these changes start occuring in dna at very early stages, long before the cancer actually develops (HCV infects chronically and people remain infected for decades before they actually develop cancer. the disease progresses step wise from simple chronic infection to cancer). wat i want to do is to obtain the samples of patients at various pre-cancerous and cancerous stages and compare them for the changes in their dna (these changes have been reported to be involved in cancer development). this study will be a little biased as we will be taking only HCV infected patients and that too from a certain locality visiting a certain hospital.
now my question is:
wat would you call this study .... cross sectional, case control.... or wat else? how would we define the study design and sampling methodology?
secondly, wat statistic tests/analysis need to be done to analyze this data, one thing that i have seen in published research of this kind is that they either use fisher's exact test or in some simpler studies they used mean SD. i simply dont understand statistics so i can get help from these papers.
I need to submit my proposal urgently otherwise i wud have educated myself before venturing into this area
Looking forward to some guiding comments. I would welcome if someone can point out flaws in my study design. and lastly it would be a real help if someone can provide me ready made answer
Thanks
I am doing my phd research in molecular biology. I am totally illiterate in statistics that is why i am facing some real problems in my proposal.
coming to the point, below i describe my project in simple words. i need you guys help and comments and suggestions for modifications
I am working on correlation of a certain abnormality in DNA of patient with hepatitis c related cancer. my hypothesis is that these changes start occuring in dna at very early stages, long before the cancer actually develops (HCV infects chronically and people remain infected for decades before they actually develop cancer. the disease progresses step wise from simple chronic infection to cancer). wat i want to do is to obtain the samples of patients at various pre-cancerous and cancerous stages and compare them for the changes in their dna (these changes have been reported to be involved in cancer development). this study will be a little biased as we will be taking only HCV infected patients and that too from a certain locality visiting a certain hospital.
now my question is:
wat would you call this study .... cross sectional, case control.... or wat else? how would we define the study design and sampling methodology?
secondly, wat statistic tests/analysis need to be done to analyze this data, one thing that i have seen in published research of this kind is that they either use fisher's exact test or in some simpler studies they used mean SD. i simply dont understand statistics so i can get help from these papers.
I need to submit my proposal urgently otherwise i wud have educated myself before venturing into this area
Looking forward to some guiding comments. I would welcome if someone can point out flaws in my study design. and lastly it would be a real help if someone can provide me ready made answer
Thanks