I have calculated sensitivities, specificities with pos and neg predictive values for different cutoff values of two biomarkers.

What i get is the following:

Biomarker 1: High spec (92%) low sens (20%) with high NPV (91%) and low PPV (22%)

Biomarker 2: High sens (90%) low spec (30%) with high NPV (96%) and low PPV (13%)

Does the high NPV for both biomarkers mean that they can be used to rule out the disease, or do you need to take in consideration the corresponding sensitivity and specificity ?

Whats is the best way to interpret these numbers ?

Thanks !