I know a little about typical design of experiments to determine the effect of factors. However, in this case, should I just see if there is any correlation of the uncontrollable (noise) factors on the results. I`m not sure yet how to go about that --- determining if the noise factors affect the results over just random variation.

It`s not clear to me how to determine how many runs I need to make for statistically valid results.

If someone could just point me in the right direction, I would appreciate it.

Thanks, Stanley