Statistical/practical significant difference

Suppose that we have two groups that they select N items. For example, in the table below, we have the number of people from each group that have selected each item.
items: A B C D E F G H K L
G1: 3 4 52 633 1000 0 6 915 890 500
G2: 1 19 17 333 1000 25 6 110 951 510
Population of group 1: 1000
Population of group 2: 1050
The populations are free to select as many of the items as they want. We do not have/know any assumption for selection of items. I want to find which items are important for discrimination between two populations by some test. Is there any test that determines the differences in which items are statistically/practically important/significant?
Thanks very much for your guidance.