Hi all,

I am writing a project proposal: randomized, placebo-controlled crossover trial, I will be investigating treatment vs air. Participants will be asked to inhale the treatment or high-flow air (placebo). In this case, would a one-tailed test or a two-tailed test be more appropriate? Furthermore, the primary endpoint will be the time to onset of pain relief - which would be the best statistical tests?

My statistical competency is not so great. I, therefore, appreciate the help and do let me know if more info is required.

Thank you in advance.

I am writing a project proposal: randomized, placebo-controlled crossover trial, I will be investigating treatment vs air. Participants will be asked to inhale the treatment or high-flow air (placebo). In this case, would a one-tailed test or a two-tailed test be more appropriate? Furthermore, the primary endpoint will be the time to onset of pain relief - which would be the best statistical tests?

My statistical competency is not so great. I, therefore, appreciate the help and do let me know if more info is required.

Thank you in advance.

Last edited: